Program
Wednesday, 16.03.2011
| 08:00 - 10:00 | Registration |
| 10:00 - 11:00 | Welcome Rainer Engers (Düsseldorf/Neuss) Key note lecture Channing Der (Chapel Hill, NC, USA) |
| 11:00 - 12:30 | Symposium 1 - Tumor Stem Cells and Reprogramming Chair: Petra Boukamp (Heidelberg), Bernd Groner (Frankfurt/M.) |
| 11:00 – 11:35 | MicroRNAs, EMT AND CANCER STEM CELLS Thomas Brabletz (Freiburg) |
| 11:35 – 12:10 | Stem cells, cancer stem cells and breast cancer
heterogeneity Matthew Smalley (London) |
| 12:10 – 12:20 | Tumour stem cells and the microenvironment Berit Falkowska-Hansen (Heidelberg) |
| 12:20 – 12:30 | Wnt/β-catenin drives MLL1 activity which locks
salivary gland cancer stem cells in a specific
epigenetic state Ulrike Ziebold (Berlin) |
| 12:30 - 13:30 | Lunch Break |
| 13:30 - 15:00 | Symposium 2 - Invasion and Metastasis
Chair: Rainer Engers (Düsseldorf/Neuss), Klaus-Peter Janssen (München) |
| 13:30 – 14:05 | Intravital microscopy of cancer invasion and
experimental therapy response: how to overcome
resistance niches Peter Friedl (Nijmegen) |
| 14:05 – 14:40 | Unraveling Breast to Lung Metastasis Suppressor
Functions Roger Gomis (Barcelona) |
| 14:40 – 14:50 | Role of breast cancer susceptibility gene 2
(BRCA2) in Tiam1-dependent adhesion, migration and
invasion Eva Margarethe Müller (Düsseldorf) |
| 14:50 – 15:00 | Tumor-microenvironment interactions studied by
zonal transcriptional profiling of squamous cell
lung carcinoma Hui Wu (Heidelberg) |
| 15:00 - 17:00 | Poster Session 1 and Coffee |
| 17:00 - 18:30 | Symposium 3 - Mouse Models Chair: Iduna Fichtner (Berlin), Klaus-Peter Janssen (München) |
| 17:00 – 17:35 | Targeting DNA repair deficiencies in mouse
models of hereditary breast cancer Jos Jonkers (Amsterdam) |
| 17:35 – 18:10 | Patient-derived cancer xenografts - a
preclinical model system for the identification of
biomarkers and for the development of targeted
therapies Iduna Fichtner (Berlin) |
| 18:10 – 18:20 | Mouse lessons on tumor drug resistance and on
the mechanisms of side effects Jürgen Thomale (Essen) |
| 18:20 – 18:30 | Impaired liver tumor formation and oval cell
activation in the RAGE knockout mouse Tobias Pusterla (Heidelberg) |
| 19:30 | Welcome Reception |
Thursday, 17.03.2011
| 08:30 - 10:00 | Symposium 4 - Carcinogenesis, Genome
stability, DNA Damage and Repair, Epigenetics Chair: Michael Schwarz (Tübingen), Lisa Wiesmüller (Ulm) |
| 08:30 – 09:05 | Susceptibility Genes for Familial Cancers Helmut Hanenberg (Düsseldorf) |
| 09:05 – 09:40 | Loss of the tumor suppressor genes CHK2 and
BRCA1 cause chromosomal instability in human somatic
cells Holger Bastians (Göttingen) |
| 09:40 – 09:50 | An endogenous retrovirus drives hitherto unknown
pro-apoptotic p63 isoforms in the male germline of
humans and great apes Ulrike Beyer (Göttingen) |
| 09:50 – 10:00 | A ROLE FOR TELOMERE LENGTH AND ORGANISATION IN
HUMAN SKIN CARCINOGENESIS Christine Leufke (Heidelberg) |
| 10:00 - 10:15 | Coffee break |
| 10:15 - 11:45 | Symposium 5 - Oncogene Addiction Chair: Martin Eilers (Marburg), Reinhold Schäfer (Berlin) |
| 10:15 – 10:50 |
Exploiting synthetic lethality and non-oncogene addiction for cancer therapy
Stefan Fröhling (Ulm) |
| 10:50 – 11:25 | Oncogene Addiction: Inside and Out Dean Felsher (Stanford, USA) |
| 11:25 – 11:35 | Regulation of EZH2 via MAPK signalling, c-MYC
and miRNA 101 in colorectal cancer cell lines Christine Sers (Berlin) |
| 11:35 – 11:45 | Eliminating Cancer Stem Cells by Inhibition of
the Wnt Pathway via Small Molecule Kinase Inhibitors
Hella Kohlhof (Martinsried) |
| 11:45 - 12:30 | Key Note Lecture 2 Klaus Pantel (Hamburg) |
| 12:30 - 13:30 | Lunch Break |
| 13:30 - 15:00 | Symposium 6 - Tumor Metabolism Chair: Ivan Dikic (Frankfurt), Matthias Dobbelstein (Göttingen) |
| 13:30 – 14:05 | Autophagy and ATP release: metabolsim determines
the chemotherapy-induced anticancer immune response
Guido Kroemer (Paris) |
| 14:05 – 14:40 | Ubiquitin networks in cancer Ivan Dikic (Frankfurt) |
| 14:40 – 14:50 | The danger signaling protein HMGB1 induces a
novel form of cell death accompanied by formation of
giant mitochondria Wilfried Roth (Heidelberg) |
| 14:50 – 15:00 | Horizontal transfer of genetic information by
mean of extracellular vesicles: the role in
tumorigenesis and potential application in tumor
diagnostic Irina Nazarenko (Eggenstein-Leopoldshafen) |
| 15:00 - 17:00 | Poster session 2 and Coffee |
| 17:00 - 18:00 | Cancer Awards |
| 18:00 - 19:00 | AEK Member Assembly |
| from 20:00 | Social Get-together (45,00
€/ticket) Hausbrauerei „Zum Schlüssel“ (Bolkerstraße 41 – 47|40213 Düsseldorf) |
Friday, 18.03.2011
| 08:30 - 10:00 | Symposium 7 - Molecular Diagnostics and
Targeted Therapy Chair: Rainer Engers (Düsseldorf/Neuss), Roland Moll (Marburg) |
| 08:30 – 09:05 | Personalized Therapy of Lung Cancer Jürgen Wolf (Köln) |
| 09:05 – 09:40 | Predictive Biomarkers in the targeted therapy of
colorectal cancer Andreas Jung (München) |
| 09:40 – 09:50 | Specific targeting of colorectal and pancreatic
cancer with Shiga toxin B-subunit Matthias Maak (München) |
| 09:50 – 10:00 | Na+K+ATPase activity might be the crucial factor
for selective inhibition of tumor stem cells Helmut Bühler (Herne) |
| 10:00 - 10:15 | Coffee break |
| 10:15 - 11:45 | Symposium 8 - Novel Approaches to
Therapy Chair: Klaus Bosslet (Berlin), Jens Hoffmann (Berlin) |
| 10:15 – 10:50 | Vascular tumor targeting Dario Neri (Zürich) |
| 10:50 – 11:25 | Cyclins and CDKs as targets for tumor therapies
Nisar Malek (Hannover) |
| 11:25 – 11:35 | The radiosensitizing effect of Cetuximab is
attenuated by activation of JNK2 signaling Iris Eke (Dresden) |
| 11:35 – 11:45 | Radiotherapy stimulates pro-metastatic normal
tissue responses, which are attenuated by the
lipid-lowering drug lovastatin Gerhard Fritz (Mainz) |
| 11:45 - 12:30 | Key note Lecture 3 Carlo Croce (Columbus, OH, USA) |
| 12:30 - 13:30 | Lunch Break |
| 13:30 - 15:00 | Symposium 9 - Tumor Inflammation and
Immunology Chair: Martin Lipp (Berlin), Winfried Wels (Frankfurt) |
| 13:30 – 14:05 | Intratumoral immune reaction, a novel paradigm
for cancer Jérôme Galon (Paris) |
| 14:05 – 14:40 | Novel functions of NF-kappaB in inflammation and
cancer Florian Greten (München) |
| 14:40 – 14:50 | Activity of ER Aminopeptidase 1 in Malignant
Melanoma Determines the Strength of the Overall CD8+
T Cell Response Against Autologous Tumor Cells Christin Seifert (Essen) |
| 14:50 – 15:00 | CXC-CHEMOKINES AS CRUCIAL IMMUNE MEDIATORS IN
COLORECTAL CARCINOGENESIS Larissa Keller (München) |
| 15:00 - 15:30 | Poster Prizes and concluding remarks
Rainer Engers (Düsseldorf/Neuss) |