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| 08:30 a.m. – 10:00 a.m. |
Registration |
| 10:00 a.m. – 10:15 a.m. |
Welcome Congress Chair: Martin Eilers (Wuerzburg, Germany) AEK Chair: Rainer Engers (Duesseldorf, Germany) Deutsche Krebshilfe: Franz Kohlhuber (Bonn, Germany) |
| 10:15 a.m –11:45 a.m. |
Symposium 1: Metabolism & Senescence |
| 10:15 a.m –10:45 a.m. |
Nutrient dependencies of metastasis formation Sarah-Maria Fendt (VIB-KU, Leuven, Belgium) |
| 10:45 a.m. - 11:15 a.m. |
Cellular functionality and plasticity in the senescence spectrum |
| 11:15 a.m. - 11:30 a.m. |
Abstracts Short Talk I: Metabolic bottlenecks shape tumor-specific dependencies in pancreatic cancer |
| 11:30 a.m. - 11:45 a.m. |
Abstract Short Talk II: Spontaneous Intratumoral Senescence drives Cancer Metastasis |
| 11:45 a.m. - 01:00 a.m |
Lunch Break |
| 01:00 p.m. – 03:00 p.m. |
Symposium 2: Transcription and RNA metabolis |
| 01:00 p.m. - 01:30 p.m. |
Transcriptional dependencies of tuft cell lung carcinomas |
| 01:30 p.m. - 02:00 p.m. |
Targeting RNA modifications in cancer |
| 02:00 p.m. - 02:30 p.m. |
MYC drives small cell lung cancer (SCLC) subtype plasticity |
| 02:30p.m. - 02:45 p.m. |
Abstract Short Talk I: MYCN exists in competing RNA- and DNA-bound complexes |
| 02:30 p.m. - 03:00 p.m. |
Abstract Short Talk II: The SWI/SNF nucleosome remodeling complex core subunit SMARCC1 mediates oncogenic NOTCH1-signaling in T-cell acute lymphoblastic leukemia |
| 03:00p.m. - 03:15p.m. |
Poster Flash Talk Session 1 (2.30 minutes each Poster) Poster Flash Talk I: Exploring rational combinations for KRAS inhibition through functional genomics Poster Flash Talk II: Complexes of MYC and PAF1 suppress transcription-replication conflicts and enable immune evasion of pancreatic carcinoma Poster Flash Talk III: The composition and funktionality of T-cells depend on risk status in multiple myeloma Poster Flash Talk IV: Spatial transcriptomics reveals a multi cellular ecosystem in extramedullary multiple myeloma Poster Flash Talk V: The Role of the EMT-Transcription Factor Zeb1 in CAFs for Metastatic Colonization and Growth Poster Flash Talk VI: EVI1 drives leukemogenesis through aberrant ERG activation |
| 03:15 p.m. - 05:00 p.m. | Coffee Break and Poster Session 1 |
| 05:00 p.m. - 06:30 p.m. |
Symposium 3: Immunity |
| 05:00 p.m. - 05:30 p.m. |
Engineering immune cells to prevent and fight cancer |
| 05:30 p.m. - 06:00 p.m. |
Peptide-based Immunotherapy of Cancer |
| 06:00 p.m. - 06:15 p.m. |
Abstract Short Talk I: CIC orchestrates T cell mediated tumor control as a key regulator of the RAF-MEK-ERK signaling pathway |
| 06:15 p.m. - 06:30 p.m. | Abstract Short Talk II: Overexpression of a lymphoid homing receptor confers anti-CXCR5 CAR T cells with increased dissemination to lymph nodes and enhanced cytotoxicity toward B cell lymphoma Mario Bunse (Berlin, Germany) |
| 06:30 p.m. | Welcome Reception |
| 09:00 a.m. – 11:00 a.m. | Symposium 4: Gastrointestinal Cancers Chair: Lars Zender (Tuebingen, Germany) |
| 09:00 a.m. – 09:30 a.m. |
"Of mice and men”: Translational immune studies in liver cancer |
| 09:30 a.m. - 10:00 a.m. |
Dissecting progressive plasticity of colorectal cancer metastasis |
| 10:00 a.m. – 10:30 a.m. |
Clone wars: evolution of adaptation and malignancy in the liver |
| 10:30 a.m. – 10:45 a.m. |
Abstract Short Talk I: The gut microbiome is crucial for liver regeneration and lipid metabolism after resection |
| 10:45 a.m. – 11:00 a.m. |
Abstract Short Talk II: Humanized mouse models for preclinical evaluation of novel immune cell therapies, check point inhibitors, and immune cell engagers |
| 11:00 a.m. – 11:30 a.m. | Coffee break |
| 11:30 a.m. - 01:00 p.m. |
Symposium 5: Small molecules I Chair: Johannes Zuber (Vienna, Austria) |
| 11:30 a.m. – 12:00 p.m. |
PROTACs and Targeted Protein Degradation: A New Therapeutic Modality |
| 12:00 p.m. – 12:30 p.m. |
Hijacking the Ubiquitin System for Protein Degradation Therapeutics |
| 12:30 p.m. – 12:45 p.m. |
Abstract Short Talk I: Targeted protein degraders of Aurora-A reduce N-myc levels in neuroblastoma in vivo |
| 12:45 p.m. - 01:00 p.m. | Abstract Short Talk II: Targeting Spliceosome as an anti-cancer therapeutic strategy for aggressive MYC-driven tumors Cristian Prieto-Garcia (Frankfurt/Main, Germany) |
| 01:00 p.m. - 02:00 p.m. | Lunch Break |
| 02:00 p.m. - 03:30 p.m. |
Symposium 6: Smal molecules II |
| 02:00 p.m. - 02:30 p.m. |
Targeting gene control by molecular glue degraders |
| 02:30 p.m. - 03:00 p.m. |
Selective targeting of protein kinase catalytic and scaffolding function |
| 03:00 p.m. - 03:15 p.m | Abstract Short Talk I: Deciphering Cell Cycle Plasticity to ERK Inhibition in KRAS-driven Pancreatic Cancer Cells at the Single-cell Level Björn Papke (Berlin, Germany/Chapel Hill, United States) |
| 03:15 p.m. - 03:30 p.m. |
Abstract Short Talk II: Efficient Correction of Oncogenic KRAS and TP53 Mutations through CRISPR Base Editing |
| 03:30 p.m. – 04:00 p.m. |
Poster Flash Talks Seission 2 |
| Poster Flash Talk I: Targeting the Hippo signaling coactivators, YAP and TAZ, in cancer Marco Gründl (Jena, Germany) |
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| Poster Flash Talk II: Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2 Markus Vogt (Wuerzburg, Germany) |
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| Poster Flash Talk III: Small molecules target MYC-driven metabolic dependences in pancreatic cancer Bastian Krenz (Wuerzburg, Germany) |
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| Poster Flash Talk IV: A systematic screen for interstitial fluid metabolites that support metastatic seeding in breast cancer Greta Mattavelli (Wuerzburg, Germany) |
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| Poster Flash Talk V: cPLA2 expression correlates with enhanced invasion of osteosarcoma cells in zebrafish xenografts Martin Distel (Vienna, Austria) |
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| Poster Flash Talk VI: The function of the BH3-only protein NOXA for BH3-mimetic-induced apoptosis in lymphoma cells Marius Anders (Frankfurt/Main, Germany) |
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| Poster Flash Talk VII: Novel type 1.5 p38alpha inhibitors block colorectal cancer development by inducing mitotic catastrophe Daniel Dauch (Tuebingen, Germany) |
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Poster Flash Talk VIII: BCAT1 regulates glioblastoma cell plasticity and differentiation |
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Poster Flash Talk IX: Deciphering microbial dependencies of tumorigenesis using novel mouse models of colorectal cancer |
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Poster Flash Talk X: Therapeutic Targeting of a Senescence associated Immune Checkpoints unleashes anti-tumor Immune Responses |
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| 04:00 p.m. - 06:00 p.m. |
Coffee break & Poster Session II |
| 06:00 p.m. - 07:00 p.m. |
Keynote Lecture: Inflammatory Signaling in Prostate Cancer |
| 08:00 p.m. |
Conference Dinner and Party |
| 09:00 a.m. – 12:00 a.m. |
Symposium 7: Tumors with undruggable oncogenes Chair: Jens Hoffmann (Berlin, Germany); Lisa Wiesmüller (Ulm, Germany) |
| 09:00 a.m. - 09:30 a.m. |
The genomic and spatial mobility of extrachromosomal DNA and its implications for cancer therapy |
| 09:30 a.m. - 10:00 a.m. |
Using mouse models to conceptualize novel cancer treatments |
| 10:00 a.m. - 10:15 a.m. | Abstract Short Talk I: Tumor-draining lymph node fibroblasts support pre-metastatic niche formation by promoting immunosuppressive cellular networks Angela Riedel (Wuerzburg, Germany) |
| 10:15 a.m. - 10:30 a.m. | Poster Awards |
| 10:30 a.m. - 11:00 a.m. |
Coffee break |
| 11:00 a.m. - 11:30 a.m. |
Minor intron splicing is critical for survival of lethal prostate cancer |
| 11:30 a.m. - 12:00 p.m. |
Targeting cancer cells by inducing Ferroptosis |
| 12:30 p.m. - 02:00 p.m. | AEK Member Assembly |
Subject to change without notice. Last Changes: January 5th, 2023.
Transparency specifications
The content of the 21st International AEK Cancer Congress in Kassel will be designed to be product and service neutral. We confirm that the scientific management and the speakers disclose potential conflicts of interest to the participants. There is no sponsorship of the event, the total expenses of the event amount to approx. 169,645.76 €.