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February 15th, 2023
08:30 a.m. – 10:00 a.m.
10:00 a.m. – 10:15 a.m.
Congress Chair: Martin Eilers (Wuerzburg, Germany)
AEK Chair: Rainer Engers (Duesseldorf, Germany)
Deutsche Krebshilfe: Franz Kohlhuber (Bonn, Germany)
10:15 a.m –11:45 a.m.

Symposium 1: Metabolism & Senescence
Chair: Christine Sers (Berlin, Germany)

10:15 a.m –10:45 a.m.
Nutrient dependencies of metastasis formation
Sarah-Maria Fendt (VIB-KU, Leuven, Belgium)

10:45 a.m. - 11:15 a.m.

Cellular functionality and plasticity in the senescence spectrum
Masashi Narita (RUK, Cambridge, UK)

11:15 a.m. - 11:30 a.m.

Abstracts Short Talk I: Metabolic bottlenecks shape tumor-specific dependencies in pancreatic cancer
Robert Kalis (Vienna, Austria)

11:30 a.m. - 11:45 a.m.

Abstract Short Talk II: Spontaneous Intratumoral Senescence drives Cancer Metastasis
Omelyan Trompak (Tuebingen, Germany)

11:45 a.m. - 01:00 a.m
Lunch Break
01:00 p.m. – 03:00 p.m.

Symposium 2: Transcription and RNA metabolis
Chair: Matthias Dobbelstein (Goettingen, Germany)

01:00 p.m. - 01:30 p.m.

Transcriptional dependencies of tuft cell lung carcinomas
Chris Vakoc (CSHL, Cold Spring Harbor, USA)

01:30 p.m. - 02:00 p.m.

Targeting RNA modifications in cancer
Michaela Frye (DKFZ, Heidelberg, Germany)

02:00 p.m. - 02:30 p.m.

MYC drives small cell lung cancer (SCLC) subtype plasticity
Trudy G. Oliver (Duke, Durham, USA)

02:30p.m. - 02:45 p.m.

Abstract Short Talk I: MYCN exists in competing RNA- and DNA-bound complexes
Dimitrios Papadopoulos (Wuerzburg, Germany)

02:30 p.m. - 03:00 p.m.

Abstract Short Talk II: The SWI/SNF nucleosome remodeling complex core subunit SMARCC1 mediates oncogenic NOTCH1-signaling in T-cell acute lymphoblastic leukemia
Khalid Shoumariyeh (Freiburg, Germany)

03:00p.m. - 03:15p.m.

Poster Flash Talk Session 1 (2.30 minutes each Poster)
Chairs: Daniel Dauch (Tuebingen, Germany)

Poster Flash Talk I:  Exploring rational combinations for KRAS inhibition through functional genomics
Bettina Sajtos (Vienna, Austria)

Poster Flash Talk II: Complexes of MYC and PAF1 suppress transcription-replication conflicts and enable immune evasion of pancreatic carcinoma
Abdallah Gaballa (Wuerzburg, Germany)

Poster Flash Talk III: The composition and funktionality of T-cells depend on risk status in multiple myeloma
Mara John (Wuerzburg, Germany)

Poster Flash Talk IV: Spatial transcriptomics reveals a multi cellular ecosystem in extramedullary multiple myeloma
Nazia Afrin (Wuerzburg, Germany)

Poster Flash Talk V: The Role of the EMT-Transcription Factor Zeb1 in CAFs for Metastatic Colonization and Growth
Elisabetta D’Avanzo (Erlangen, Germany)

Poster Flash Talk VI: EVI1 drives leukemogenesis through aberrant ERG activation
Johannes Schmoellerl (Vienna, Austria)

03:15 p.m. - 05:00 p.m. Coffee Break and Poster Session 1
05:00 p.m. - 06:30 p.m.

Symposium 3: Immunity
Chair: Angela Riedel (Wuerzburg, Germany)

05:00 p.m. - 05:30 p.m.

Engineering immune cells to prevent and fight cancer
Judith Feucht (Tübingen University, Germany)

05:30 p.m. - 06:00 p.m.

Peptide-based Immunotherapy of Cancer
Juliane Walz (Tübingen University, Germany)

06:00 p.m. - 06:15 p.m.

Abstract Short Talk I: CIC orchestrates T cell mediated tumor control as a key regulator of the RAF-MEK-ERK signaling pathway
Markus Schäfer (Vienna, Austria)

06:15 p.m. - 06:30 p.m. Abstract Short Talk II: Overexpression of a lymphoid homing receptor confers anti-CXCR5 CAR T cells with increased dissemination to lymph nodes and enhanced cytotoxicity toward B cell lymphoma
Mario Bunse (Berlin, Germany)

06:30 p.m. Welcome Reception

February 16th, 2023
09:00 a.m. – 11:00 a.m. Symposium 4: Gastrointestinal Cancers
Chair: Lars Zender (Tuebingen, Germany)
09:00 a.m. – 09:30 a.m.

"Of mice and men”: Translational immune studies in liver cancer
Tim Greten (NCI, Bethesda, USA)

09:30 a.m. - 10:00 a.m.

Dissecting progressive plasticity of colorectal cancer metastasis
Karuna Ganesh (MSKCC, New York, USA)

10:00 a.m. – 10:30 a.m.

Clone wars: evolution of adaptation and malignancy in the liver
Hao Zhu (UT Southwestern, Dallas, USA)

10:30 a.m. – 10:45 a.m.

Abstract Short Talk I: The gut microbiome is crucial for liver regeneration and lipid metabolism after resection
Anna Sichler (Munich, Germany)

10:45 a.m. – 11:00 a.m.

Abstract Short Talk II: Humanized mouse models for preclinical evaluation of novel immune cell therapies, check point inhibitors, and immune cell engagers
Jens Hoffmann (Berlin, Germany)

11:00 a.m. – 11:30 a.m. Coffee break
11:30 a.m. - 01:00 p.m.
Symposium 5: Small molecules I
Chair: Johannes Zuber (Vienna, Austria)
11:30 a.m. – 12:00 p.m.

PROTACs and Targeted Protein Degradation:  A New Therapeutic Modality
Craig Crews (Yale University, USA)

12:00 p.m. – 12:30 p.m.

Hijacking the Ubiquitin System for Protein Degradation Therapeutics
Eric Fischer (DFCI, Boston, USA)

12:30 p.m. – 12:45 p.m.

Abstract Short Talk I: Targeted protein degraders of Aurora-A reduce N-myc levels in neuroblastoma in vivo
Elmar Wolf (Wuerzburg, Germany)

12:45 p.m. - 01:00 p.m. Abstract Short Talk II: Targeting Spliceosome as an anti-cancer therapeutic strategy for aggressive MYC-driven tumors
Cristian Prieto-Garcia (Frankfurt/Main, Germany)

01:00 p.m. - 02:00 p.m. Lunch Break
02:00 p.m. - 03:30 p.m.

Symposium 6: Smal molecules II
Chair: Beate Volkmer (Buxtehude, Germany)

02:00 p.m. - 02:30 p.m.

Targeting gene control by molecular glue degraders
Georg Winter (CeMM, Vienna, Austria)

02:30 p.m. - 03:00 p.m.

Selective targeting of protein kinase catalytic and scaffolding function
Stefan Knapp (SGC, Frankfurt University, Germany)

03:00 p.m. - 03:15 p.m Abstract Short Talk I: Deciphering Cell Cycle Plasticity to ERK Inhibition in KRAS-driven Pancreatic Cancer Cells at the Single-cell Level
Björn Papke (Berlin, Germany/Chapel Hill, United States)
03:15 p.m. - 03:30 p.m.

Abstract Short Talk II: Efficient Correction of Oncogenic KRAS and TP53 Mutations through CRISPR Base Editing
Shady Sayed (Dresden, Germany)

03:30 p.m. – 04:00 p.m.

Poster Flash Talks Seission 2
Chair: Elmar Wolf (Wuerzburg, Germany)

Poster Flash Talk I: Targeting the Hippo signaling coactivators, YAP and TAZ, in cancer
Marco Gründl (Jena, Germany)

Poster Flash Talk II: Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2
Markus Vogt (Wuerzburg, Germany)

Poster Flash Talk III: Small molecules target MYC-driven metabolic dependences in pancreatic cancer
Bastian Krenz (Wuerzburg, Germany)

Poster Flash Talk IV: A systematic screen for interstitial fluid metabolites that support metastatic seeding in breast cancer
Greta Mattavelli (Wuerzburg, Germany)

Poster Flash Talk V: cPLA2 expression correlates with enhanced invasion of osteosarcoma cells in zebrafish xenografts
Martin Distel (Vienna, Austria)

Poster Flash Talk VI: The function of the BH3-only protein NOXA for BH3-mimetic-induced apoptosis in lymphoma cells
Marius Anders (Frankfurt/Main, Germany)

Poster Flash Talk VII: Novel type 1.5 p38alpha inhibitors block colorectal cancer development by inducing mitotic catastrophe
Daniel Dauch (Tuebingen, Germany)

Poster Flash Talk VIII: BCAT1 regulates glioblastoma cell plasticity and differentiation
Pavle Boskovic (Heidelberg, Germany)

Poster Flash Talk IX: Deciphering microbial dependencies of tumorigenesis using novel mouse models of colorectal cancer
Valentina Brunner (Munich, Germany)

Poster Flash Talk X: Therapeutic Targeting of a Senescence associated Immune Checkpoints unleashes anti-tumor Immune Responses
Jorge Abreu-Macedo (Tuebingen, Germany)

04:00 p.m. - 06:00 p.m.
Coffee break & Poster Session II
06:00 p.m. - 07:00 p.m.

Keynote Lecture: Inflammatory Signaling in Prostate Cancer
Chair: Martin Eilers (Wuerzburg, Germany)

Charles Sawyers (MSKCC, New York, USA)

08:00 p.m.

Conference Dinner and Party


February 17th, 2023
09:00 a.m. 12:00 a.m.
Symposium 7: Tumors with undruggable oncogenes
Chair: Jens Hoffmann (Berlin, Germany); Lisa Wiesmüller (Ulm, Germany)
09:00 a.m. - 09:30 a.m.

The genomic and spatial mobility of extrachromosomal DNA and its implications for cancer therapy
Anton Henssen (Charité, Berlin, Germany)

09:30 a.m. - 10:00 a.m.

Using mouse models to conceptualize novel cancer treatments
Christian Reinhardt (Essen University, Germany)

10:00 a.m. - 10:15 a.m. Abstract Short Talk I: Tumor-draining lymph node fibroblasts support pre-metastatic niche formation by promoting immunosuppressive cellular networks
Angela Riedel (Wuerzburg, Germany)

10:15 a.m. - 10:30 a.m. Poster Awards
10:30 a.m. - 11:00 a.m.
Coffee break
11:00 a.m. - 11:30 a.m.

Minor intron splicing is critical for survival of lethal prostate cancer
Mark Rubin (University of Bern, Switzerland)

11:30 a.m. - 12:00 p.m.

Targeting cancer cells by inducing Ferroptosis
Andreas Trumpp (DKFZ, Heidelberg, Germany)

12:30 p.m. - 02:00 p.m. AEK Member Assembly


Subject to change without notice. Last Changes: January 5th, 2023.

Transparency specifications

The content of the 21st International AEK Cancer Congress in Kassel will be designed to be product and service neutral. We confirm that the scientific management and the speakers disclose potential conflicts of interest to the participants. There is no sponsorship of the event, the total expenses of the event amount to approx. 169,645.76 €.